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Metabolism 164:156113 Linge J, Birkenfeld AL, Neeland IJ (2024) Muscle mass and Glucagon-Like Peptide-1 receptor agonists: adaptive or maladaptive response to weight loss

TL;DR Rybelsus (oral semaglutide) is a GLP-1 receptor agonist that delivers stronger weight loss (12-15% of body weight) and A1C reduction (-1.8%) than metformin (3-5% weight loss, -1.5% A1C), but costs roughly $936-$998 per month compared to metformins $4-$10 generic price

In diabetic neuropathy, microangiopathy damages these vessels, starving nerves of the resources needed for survival and repair